In this phase 3, multicenter, open-label, randomized trial, we assigned patients with previously untreated HER2-expressing (immunohistochemical score of 1+, 2+, or 3+) locally advanced or metastatic urothelial cancer in a 1:1 ratio to receive either disitamab vedotin plus PD-1–specific toripalimab every 2 weeks or chemotherapy (gemcitabine plus cisplatin or carboplatin) every 3 weeks. The dual primary end points were progression-free survival (assessed by blinded independent review) and overall survival. Secondary end points included objective response and safety. Here we report the prespecified progression-free survival analysis and interim overall survival analysis. but commonly cited examples include Worcestershire, acquiesce, chrysanthemum, and sesquipedalian due to their unusual letter combinations or silent letters. Other challenging words are often technical, long, or have confusing vowel patterns, like psychotomimetic or onimonomatopoeia. Pneumonoultramicroscopicsilicovolcanoconiosis, a technical term for a lung disease from inhaling volcanic dust, followed by Pseudopseudohypoparathyroidism and Floccinaucinihilipilification the longest non-technical word). Other notable long words include the famous Antidisestablishmentarianism and the fictional Supercalifragilisticexpialidocious. Mengetik merupakan keterampilan penting yang harus dikuasai di era digital karena hampir seluruh aktivitas pendidikan, administrasi, dan pekerjaan dilakukan dengan bantuan komputer atau perangkat elektronik lainnya. Kemampuan mengetik yang baik tidak hanya berkaitan dengan kecepatan, tetapi juga dengan ketepatan, kerapian, dan konsistensi dalam menuliskan kata maupun kalimat. Seseorang yang terbiasa mengetik dengan benar akan lebih mudah menuangkan ide dan gagasan tanpa harus sering berhenti untuk memperbaiki kesalahan penulisan. Selain itu, keterampilan mengetik yang terlatih dapat membantu meningkatkan konsentrasi, karena tangan dapat bergerak secara otomatis tanpa harus selalu melihat papan ketik. Dalam jangka panjang, kebiasaan mengetik yang baik juga dapat menghemat waktu, meningkatkan produktivitas kerja, serta mendukung penyelesaian tugas secara lebih efisien dan profesional. Oleh sebab itu, latihan mengetik secara rutin dengan teks yang cukup panjang sangat dianjurkan agar kemampuan ini terus berkembang dan semakin optimal. BCL3 is a proto-oncogene affected by chromosomal translocations in some patients with chronic lymphocytic leukemia. It is an IkappaB family protein that is involved in transcriptional regulation of a number of NF-kappaB target genes. In this study, interleukin (IL)-6-induced BCL3 expression and its effect on survival of multiple myeloma (MM) cells were examined. We demonstrate the upregulation of BCL3 by IL-6 in INA-6 and other MM cell lines. Sequence analysis of the BCL3 gene locus revealed four potential signal transducer and activator of transcription (Stat) binding sites within two conserved intronic enhancers regions: one located within enhancer HS3 and three within HS4. Chromatin immunoprecipitation experiments showed increased Stat3 binding to both enhancers upon IL-6 stimulation. Silencing Stat3 expression by small interfering RNA (siRNA) abrogated BCL3 expression by IL-6. Using reporter gene assays, we demonstrate that BCL3 transcription depends on HS4. Mutation of the Stat motifs within HS4 abolished IL-6-dependent BCL3 induction. Furthermore, BCL3 transcription was inhibited by its own gene product. This repressive feedback is mediated by NF-kappaB sites within the promoter and HS3. Finally, we show that overexpression of BCL3 increases apoptosis, whereas BCL3-specific siRNA does not affect the viability of INA-6 cells suggesting that BCL3 is not essential for the survival of these cells.